Zexa syrup

Zexa syrup is a pharmaceutical formulation containing Memantine Hydrochloride, primarily prescribed for managing moderate to severe Alzheimer’s disease. Manufactured by A’raf Pharmaceuticals, each 5 ml of Zexa Syrup delivers 10 mg of Memantine HCl, and it is available in a 120 ml bottle.

Mechanism of Action

Memantine operates as an NMDA (N-methyl-D-aspartate) receptor antagonist. In Alzheimer’s disease, excessive stimulation of NMDA receptors by glutamate—a neurotransmitter—can lead to neuronal damage. By inhibiting this overstimulation, Memantine helps regulate glutamate activity, thereby mitigating symptoms associated with Alzheimer’s disease.

Indications

Zexa Syrup is indicated for:

• Alzheimer’s Disease: It aids in improving cognitive functions such as memory, attention, and language, and may decelerate disease progression.
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Dosage and Administration

The typical dosing regimen for Zexa Syrup is as follows:

• Week 1: 5 mg once daily.
• Week 2: Increase to 10 mg daily (5 mg twice a day).
• Week 3: Increase to 15 mg daily (5 mg in the morning and 10 mg in the evening).
• Week 4 and beyond: Increase to 20 mg daily (10 mg twice a day).

Each increment should be separated by at least one week. Zexa Syrup can be administered with or without food. It’s imperative to adhere to the prescribing physician’s instructions.

Contraindications

Zexa Syrup is contraindicated in individuals with:

• Known hypersensitivity to Memantine or any excipients in the formulation.
• Severe renal impairment.

Precautions

Caution is advised for patients with:

• Renal Impairment: Dose adjustments may be necessary.
• Hepatic Impairment: Monitor for potential adverse effects.
• Seizure Disorders: Use cautiously due to a potential increased risk of seizures.

The safety and efficacy of Memantine in pediatric patients have not been established; therefore, its use is not recommended in this population.

Drug Interactions

Memantine may interact with:

• NMDA Antagonists: Concurrent use with other NMDA antagonists (e.g., amantadine, ketamine) may increase the risk of adverse effects.
• Medications Affecting Urinary pH: Drugs that alkalinize urine can reduce Memantine elimination, potentially leading to increased plasma levels.

Patients should inform their healthcare provider of all medications they are taking to assess potential interactions.

Use in Specific Populations

• Pregnancy: Memantine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• Lactation: A decision should be made to discontinue nursing or to discontinue the drug, considering the importance of the drug to the mother.

Storage

Store Zexa Syrup at room temperature, away from light and moisture. Keep out of reach of children.

Conclusion

Zexa Syrup offers a therapeutic option for individuals with moderate to severe Alzheimer’s disease, aiming to improve cognitive function and slow disease progression. As with any medication, it is essential to use Zexa Syrup under the guidance of a qualified healthcare professional, adhering strictly to prescribed dosages and monitoring for any adverse effects.