Xedexo Capsules (3 mg/25 mg) – Olanzapine and Fluoxetine

Composition:

• Active Ingredients:
  • Olanzapine 3 mg
  • Fluoxetine 25 mg

Indications:

• Used for the treatment of:
  • Major depressive disorder (MDD)
  • Treatment-resistant depression
  • Bipolar disorder (specifically the depressive episodes)

Mechanism of Action:

• Olanzapine: An atypical antipsychotic that works by antagonizing multiple neurotransmitter receptors, including serotonin (5-HT2A) and dopamine (D2) receptors, which helps to stabilize mood and reduce depressive symptoms.
• Fluoxetine: A selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels in the brain, helping to improve mood and alleviate depressive symptoms.

Dosage:

• The usual starting dose may be one capsule taken once daily, but the specific dosage will be determined by a healthcare provider based on individual patient needs.
• Doses may be adjusted depending on response and tolerance.

Side Effects:

• Common Side Effects: Drowsiness, weight gain, dry mouth, insomnia, gastrointestinal disturbances, and sexual dysfunction.
• Serious Side Effects: Risk of serotonin syndrome, metabolic changes (such as increased blood sugar and cholesterol levels), and potential for extrapyramidal symptoms or tardive dyskinesia.

Contraindications:

• Not recommended for individuals with:
  • Known hypersensitivity to olanzapine, fluoxetine, or any components of the formulation.
  • A history of manic episodes associated with bipolar disorder (if not combined with mood stabilizers).

Storage:

• Store at room temperature, away from moisture and direct sunlight.

Precautions:

• Regular monitoring of weight, metabolic parameters, and mental status is advised, especially in long-term use.
• Caution is required in patients with a history of seizures or those who are at risk of developing serotonin syndrome.

Patient Counseling:

• Advise patients to take the medication consistently at the same time each day, with or without food.
• Discuss potential side effects, particularly those that may affect alertness or mood.
• Encourage patients to report any severe side effects, especially mood changes or signs of an allergic reaction.

For personalized advice and specific recommendations, always consult with a healthcare professional or refer to the product packaging.