Poze Tablets (30 mg) – Pioglitazone HCl

Composition:

• Active Ingredient: Pioglitazone Hydrochloride 30 mg per tablet

Indications:

• Used for the management of:
  • Type 2 diabetes mellitus, often in conjunction with diet and exercise.
  • May be used as monotherapy or in combination with other antidiabetic medications.

Mechanism of Action:

• Pioglitazone is a thiazolidinedione (TZD) that works by increasing insulin sensitivity in peripheral tissues, primarily in muscle and fat. It activates peroxisome proliferator-activated receptor gamma (PPAR-γ), which regulates gene expression involved in glucose and lipid metabolism.

Dosage:

• The usual starting dose is 15 mg to 30 mg taken once daily. The maximum recommended dose is 45 mg per day, depending on individual patient response and tolerance.
• Dosage adjustments may be necessary based on blood glucose levels and other medications being taken.

Side Effects:

• Common Side Effects: Edema, weight gain, headache, and respiratory infections.
• Serious Side Effects: Risk of heart failure, hepatotoxicity, and increased risk of bladder cancer with long-term use.

Contraindications:

• Not recommended for individuals with:
  • Known hypersensitivity to pioglitazone or any of its components.
  • Active bladder cancer or a history of bladder cancer.
  • Severe heart failure or significant fluid retention.

Storage:

• Store at room temperature, away from moisture and direct sunlight.

Precautions:

• Monitor liver function tests before and during treatment.
• Assess for signs of heart failure, particularly in patients with risk factors.

Patient Counseling:

• Advise patients to take the medication consistently at the same time each day.
• Discuss potential side effects, particularly weight gain and edema.
• Encourage lifestyle changes such as diet and exercise to improve glycemic control.
• Instruct patients to report any unusual symptoms, especially those related to liver function or signs of heart failure.

For personalized advice and specific recommendations, always consult with a healthcare professional or refer to the product packaging.