Calfina Plus Tablets (37.5 mg/325 mg) – Tramadol HCl and Paracetamol

Composition:

• Active Ingredients:
  • Tramadol Hydrochloride 37.5 mg
  • Paracetamol (Acetaminophen) 325 mg

Indications:

• Used for the management of moderate to moderately severe pain, including:
  • Postoperative pain
  • Pain associated with musculoskeletal disorders
  • Chronic pain conditions

Mechanism of Action:

• Tramadol: A centrally acting analgesic that works by binding to the mu-opioid receptors and inhibiting the reuptake of norepinephrine and serotonin, which contributes to its pain-relieving effects.
• Paracetamol: An analgesic and antipyretic that acts primarily in the central nervous system to block pain signals and reduce fever.

Dosage:

• The typical dosage is 1-2 tablets every 6 hours as needed, not exceeding 8 tablets in a 24-hour period.
• Dosage adjustments may be necessary for elderly patients or those with hepatic or renal impairment.

Side Effects:

• Common Side Effects: Nausea, dizziness, drowsiness, constipation, headache, and abdominal pain.
• Serious Side Effects: Risk of respiratory depression, potential for dependence or withdrawal symptoms with prolonged use of tramadol, and liver damage with excessive paracetamol intake.

Contraindications:

• Not recommended for individuals with:
  • Known hypersensitivity to tramadol, paracetamol, or any components of the formulation.
  • Severe respiratory depression or acute intoxication with alcohol or other central nervous system depressants.

Storage:

• Store at room temperature, away from moisture and direct sunlight.

Precautions:

• Caution is advised in patients with a history of substance abuse, liver disease, or those taking other medications that may interact with tramadol or paracetamol.
• Monitor for signs of liver dysfunction, especially in patients using high doses of paracetamol.

Patient Counseling:

• Advise patients to take the medication as directed and not to exceed the recommended dosage.
• Discuss potential side effects, especially those affecting alertness, and advise against driving or operating heavy machinery until they know how the medication affects them.
• Encourage patients to report any unusual symptoms, particularly signs of allergic reactions or liver dysfunction (e.g., jaundice).

For personalized advice and specific recommendations, always consult with a healthcare professional or refer to the product packaging.