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Sinaxamol Extra Tablets 650Mg/50Mg

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    Sinaxamol Extra Tablets are a combination medication containing Paracetamol (650 mg) and Orphenadrine Citrate (50 mg). This formulation is primarily used for the relief of pain and discomfort, particularly in cases associated with muscle spasms and tension. Below is a detailed overview of the components, uses, mechanism of action, dosage, side effects, and other relevant information.

    Active Ingredients:

    1. Paracetamol (Acetaminophen) – 650 mg:
      • A widely used analgesic (pain reliever) and antipyretic (fever reducer).
      • Effective for mild to moderate pain relief, such as headaches, toothaches, muscle aches, and fevers.
    2. Orphenadrine Citrate – 50 mg:
      • A muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to the brain.
      • Primarily used to relieve muscle spasms and associated pain.

    Uses:

    Sinaxamol Extra is indicated for:

    • Muscle Pain: Provides relief from muscle pain, spasms, and discomfort.
    • Tension Headaches: Effective for managing headaches related to muscle tension and spasms.
    • Back Pain: Often used to alleviate pain caused by muscle strain or injury.
    • Post-Surgical Pain: Can be prescribed for pain management following surgical procedures involving muscles or soft tissues.

    Mechanism of Action:

    • Paracetamol:
      • Inhibits the synthesis of prostaglandins in the brain, which are responsible for causing pain and fever. It primarily acts in the central nervous system and has a minimal anti-inflammatory effect.
    • Orphenadrine Citrate:
      • Acts as a muscle relaxant by blocking the action of certain neurotransmitters (such as acetylcholine) in the central nervous system, which reduces muscle spasms and helps alleviate pain associated with muscle tension.

    Dosage and Administration:

    • The usual dosage for adults:
      • 1-2 tablets every 6 hours as needed; do not exceed 8 tablets in 24 hours.
    • Administration:
      • Tablets should be taken with a full glass of water, preferably after meals to minimize gastrointestinal discomfort.
    • Duration of Use:
      • Should not be used for more than a few days without consulting a healthcare provider, especially if symptoms persist.

    Side Effects:

    Sinaxamol Extra is generally well-tolerated, but potential side effects may include:

    • Common Side Effects:
      • Nausea or vomiting.
      • Drowsiness or dizziness.
      • Dry mouth.
      • Constipation.
    • Serious Side Effects (rare but require immediate medical attention):
      • Allergic reactions such as rash, itching, or swelling, particularly of the face, tongue, or throat.
      • Severe dizziness or fainting.
      • Liver damage symptoms (e.g., jaundice, dark urine, severe fatigue) due to excessive paracetamol intake.
      • Respiratory depression (slowed breathing) in cases of overdose.

    Precautions:

    1. Allergy History: Inform the healthcare provider if there is a known allergy to paracetamol, orphenadrine, or any other component of the medication.
    2. Liver or Kidney Disease: Caution should be exercised in patients with liver or kidney impairment, as they may be at increased risk of side effects.
    3. Alcohol Consumption: Limit alcohol intake while using Sinaxamol Extra, as it can increase the risk of liver damage due to paracetamol.
    4. Pregnancy and Breastfeeding: Use during pregnancy or breastfeeding should be discussed with a healthcare provider, as the safety of orphenadrine in these populations is not well established.

    Drug Interactions:

    • CNS Depressants: Caution is advised when using other CNS depressants (e.g., alcohol, sedatives) as orphenadrine may enhance their effects.
    • Antidepressants: May interact with certain antidepressants and increase the risk of serotonin syndrome.
    • Anticoagulants: Paracetamol may enhance the effect of anticoagulants like warfarin when taken in high doses or for extended periods.

    Storage:

    • Store Sinaxamol Extra at room temperature, away from moisture and heat. Keep it out of reach of children.

    Key Benefits:

    1. Effective Pain Relief: Combines analgesic and muscle relaxant properties, making it suitable for various types of pain, particularly those related to muscle tension.
    2. Fast-Acting: Paracetamol provides quick relief from pain and fever, while orphenadrine helps alleviate muscle spasms.
    3. Convenient Dosage Form: Tablets are easy to administer and carry, making them practical for everyday use.

    Indications for Use:

    • Patients with Muscle Spasms: Especially those experiencing pain due to acute muscle strains or injuries.
    • Individuals with Tension Headaches: Where muscle tension contributes to headache symptoms.
    • Postoperative Patients: For managing pain following surgical procedures that involve muscle manipulation.

    In conclusion, Sinaxamol Extra Tablets are an effective combination medication for managing pain and muscle spasms, providing both analgesic and muscle-relaxant benefits. It is important to use this medication as directed and consult a healthcare provider for prolonged use or if symptoms persist.

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