Nebcin Injection (80 mg/2 mL) – Tobramycin

Composition:

• Active Ingredient: Tobramycin 80 mg per 2 mL

Indications:

• Used for the treatment of serious bacterial infections caused by susceptible strains of bacteria, including:
  • Respiratory tract infections
  • Urinary tract infections
  • Intra-abdominal infections
  • Bone and joint infections
  • Skin and soft tissue infections

Mechanism of Action:

• Tobramycin is an aminoglycoside antibiotic that works by inhibiting bacterial protein synthesis. It binds to the 30S ribosomal subunit, causing misreading of mRNA and ultimately leading to cell death.

Dosage:

• The dosage of Tobramycin is determined by the type and severity of the infection, the patient’s renal function, and other individual factors.
• Commonly, the dose may range from 3 to 5 mg/kg/day, divided into two or three doses.
• For pediatric patients, dosing is typically based on body weight.

Side Effects:

• Common Side Effects: Nausea, vomiting, diarrhea, rash, and injection site reactions.
• Serious Side Effects: Nephrotoxicity (kidney damage), ototoxicity (hearing loss), and neuromuscular blockade, especially in patients with pre-existing conditions.

Contraindications:

• Not recommended for individuals with:
  • Known hypersensitivity to tobramycin or other aminoglycosides.
  • Pre-existing kidney dysfunction.

Storage:

• Store in a cool, dry place away from light. After reconstitution, the solution should be used promptly or stored in the refrigerator and used within a specified timeframe.

Precautions:

• Renal function should be monitored during therapy, as adjustments to dosing may be necessary in patients with impaired renal function.
• Caution is advised in patients with hearing impairment or those on concurrent nephrotoxic medications.

Patient Counseling:

• Instruct patients to report any signs of hearing loss, dizziness, or changes in urine output.
• Emphasize the importance of completing the full course of treatment, even if symptoms improve early.
• Discuss potential side effects and the need for regular monitoring during treatment.

For personalized advice and specific recommendations, always consult with a healthcare professional or refer to the product packaging.